Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Nkx2-5  NK2 homeobox 5   (Synonyms: Csx, Nkx-2.5, Nkx2.5, tinman)
Results	Reference
1*	J:231312 Baardman ME, Zwier MV, Wisse LJ, Gittenberger-de Groot AC, Kerstjens-Frederikse WS, Hofstra RM, Jurdzinski A, Hierck BP, Jongbloed MR, Berger RM, Plosch T, DeRuiter MC, Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25
1	J:137459 Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM, A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008 Jul 3;454(7200):104-8
1	J:297054 Cozzitorto C, Mueller L, Ruzittu S, Mah N, Willnow D, Darrigrand JF, Wilson H, Khosravinia D, Mahmoud AA, Risolino M, Selleri L, Spagnoli FM, A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation. Dev Cell. 2020 Oct 26;55(2):150-162.e6
1	J:146956 Douglas YL, Mahtab EA, Jongbloed MR, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Deruiter MC, Gittenberger-de Groot AC, Pulmonary vein, dorsal atrial wall and atrial septum abnormalities in podoplanin knockout mice with disturbed posterior heart field contribution. Pediatr Res. 2009 Jan;65(1):27-32
1*	J:236243 Gittenberger-de Groot AC, Hoppenbrouwers T, Miquerol L, Kosaka Y, Poelmann RE, Wisse LJ, Yost HJ, Jongbloed MR, Deruiter MC, Brunelli L, 14-3-3epsilon controls multiple developmental processes in the mouse heart. Dev Dyn. 2016 Nov;245(11):1107-1123
1	J:289437 Gittenberger-de Groot AC, Peterson JC, Wisse LJ, Roest AAW, Poelmann RE, Bokenkamp R, Elzenga NJ, Hazekamp M, Bartelings MM, Jongbloed MRM, DeRuiter MC, Pulmonary ductal coarctation and left pulmonary artery interruption; pathology and role of neural crest and second heart field during development. PLoS One. 2020;15(5):e0228478
1	J:192465 Huang J, Elicker J, Bowens N, Liu X, Cheng L, Cappola TP, Zhu X, Parmacek MS, Myocardin regulates BMP10 expression and is required for heart development. J Clin Invest. 2012 Oct 1;122(10):3678-91
1	J:177490 Jongbloed MR, Vicente-Steijn R, Douglas YL, Wisse LJ, Mori K, Yokota Y, Bartelings MM, Schalij MJ, Mahtab EA, Poelmann RE, Gittenberger-De Groot AC, Expression of Id2 in the second heart field and cardiac defects in Id2 knock-out mice. Dev Dyn. 2011 Nov;240(11):2561-77
1	J:294789 Kasahara H, Bartunkova S, Schinke M, Tanaka M, Izumo S, Cardiac and extracardiac expression of Csx/Nkx2.5 homeodomain protein. Circ Res. 1998 May 18;82(9):936-46
1	J:206877 Kolander KD, Holtz ML, Cossette SM, Duncan SA, Misra RP, Epicardial GATA factors regulate early coronary vascular plexus formation. Dev Biol. 2014 Feb 1;386(1):204-15
1	J:346632 Li H, Tang Q, Yang T, Wang Z, Li D, Wang L, Li L, Chen Y, Huang H, Zhang Y, Chen Y, Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development. Commun Biol. 2024 Mar 29;7(1):385
1	J:204126 Liang X, Wang G, Lin L, Lowe J, Zhang Q, Bu L, Chen Y, Chen J, Sun Y, Evans SM, HCN4 dynamically marks the first heart field and conduction system precursors. Circ Res. 2013 Aug 2;113(4):399-407
1	J:251798 Lin X, Zhao W, Jia J, Lin T, Xiao G, Wang S, Lin X, Liu Y, Chen L, Qin Y, Li J, Zhang T, Hao W, Chen B, Xie R, Cheng Y, Xu K, Yao K, Huang W, Xiao D, Sun Y, Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality. Sci Rep. 2016 Sep 30;6:34501
1*	J:142644 Mahtab EA, Vicente-Steijn R, Hahurij ND, Jongbloed MR, Wisse LJ, Deruiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Podoplanin deficient mice show a rhoa-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Dev Dyn. 2008 Dec 18;238(1):183-193
1*	J:293579 Moumne O, Chowdhurry R, Doll C, Pereira N, Hashimi M, Grindrod T, Dollar JJ, Riva A, Kasahara H, Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies. Front Cardiovasc Med. 2018;5:100
1	J:288301 Mu Y, Yu H, Wu T, Zhang J, Evans SM, Chen J, O-linked beta-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1. PLoS Genet. 2020 Apr;16(4):e1008730
1	J:266206 Peterson JC, Chughtai M, Wisse LJ, Gittenberger-de Groot AC, Feng Q, Goumans MTH, VanMunsteren JC, Jongbloed MRM, DeRuiter MC, Nos3 mutation leads to abnormal neural crest cell and second heart field lineage patterning in bicuspid aortic valve formation. Dis Model Mech. 2018 Sep 20;:dmm034637
1	J:205035 Rudat C, Kispert A, Wt1 and epicardial fate mapping. Circ Res. 2012 Jul 6;111(2):165-9
1*	J:186546 Scherptong RW, Jongbloed MR, Wisse LJ, Vicente-Steijn R, Bartelings MM, Poelmann RE, Schalij MJ, Gittenberger-De Groot AC, Morphogenesis of outflow tract rotation during cardiac development: The pulmonary push concept. Dev Dyn. 2012 Sep;241(9):1413-22
1*	J:48404 Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H, Lee Y, Lyons GE, Izumo S, Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development. Dev Genet. 1998;22(3):239-49
1	J:128986 van Loo PF, Mahtab EA, Wisse LJ, Hou J, Grosveld F, Suske G, Philipsen S, Gittenberger-de Groot AC, Transcription factor Sp3 knockout mice display serious cardiac malformations. Mol Cell Biol. 2007 Dec;27(24):8571-82
1	J:333401 van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Houweling AC, Scholman KT, Wakker V, Allaart CP, Uhm JS, Mathijssen IB, Baartscheer T, Postma AV, Barnett P, Verkerk AO, Boukens BJ, Christoffels VM, Patient-Specific TBX5-G125R Variant Induces Profound Transcriptional Deregulation and Atrial Dysfunction. Circulation. 2022 Feb 22;145(8):606-619
1	J:226315 Ye W, Wang J, Song Y, Yu D, Sun C, Liu C, Chen F, Zhang Y, Wang F, Harvey RP, Schrader L, Martin JF, Chen Y, A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node. Development. 2015 Jul 15;142(14):2521-32
1	J:177189 Zeng B, Ren XF, Cao F, Zhou XY, Zhang J, Developmental patterns and characteristics of epicardial cell markers Tbx18 and Wt1 in murine embryonic heart. J Biomed Sci. 2011;18:67
1	J:150452 Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT, Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun;119(6):1462-76
1	J:137426 Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT, Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 3;454(7200):109-13